Role of the Immune System in AIDS-defining Malignancies
Date
2022-01-01
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Coadvisor
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Volume Title
Publisher
Springer
Language
English
Alternative Title
Abstract
The Center for Disease Control and Prevention considers AIDS-defining illnesses Kaposi’s sarcoma, non-Hodgkin’s lymphoma and cervical cancer. These cancers have higher incidence in HIV-infected individuals than in the general population. Additionally, cancers’ clinical courses in HIV-positive individuals are increasingly aggressive when compared to those in HIV-negative patients. It is thus compelling to further understand the dynamics of AIDS-related cancer growth. We propose a non-integer order model to describe the role of the immune system in cancer cells’ growth in a HIV-infected individual. The model incorporates anti-retroviral therapy and chemotherapy. We simulate the model for different proliferation functions of the cytotoxic T lymphocytes (CTLs), and other parameters, namely the HIV-infection rate, the elimination rate of infected T cells by CTLs, and the elimination rate of cancer cells by the immune system and discuss the results from a physiological perspective. The order of the fractional derivative completes the discussion of the results.
Keywords
Immune System, AIDS
Document Type
Conference paper
Version
Publisher Version
Citation
Carvalho, J. M, & Pinto, C. M. A. (2022). Role of the Immune System in AIDS-defining Malignancies. In J. Awrejcewicz (Ed.), Perspectives in Dynamical Systems I: Mechatronics and Life Sciences. DSTA 2019. Springer Proceedings in Mathematics & Statistics, Łódź, Poland 2-5 December 2019, (vol. 362, pp. 95-105). Springer. https://doi.org/10.1007/978-3-030-77306-9_9. Repositório Institucional UPT. https://hdl.handle.net/11328/6445
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Restricted Access