Immune response dynamics

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dc.contributor.authorBurroughs, N. J.
dc.contributor.authorOliveira, B. M. P. M.
dc.contributor.authorPinto, A. A.
dc.contributor.authorFerreira, Miguel
dc.date.accessioned2025-05-29T08:32:04Z
dc.date.available2025-05-29T08:32:04Z
dc.date.issued2011-04-01
dc.description.abstractThe consequences of regulatory cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We determine the analytic formula that describes the fine balance between Regulatory cells and cells at controlled and immune response equilibrium states. We demonstrate that cytokine dependent growth exhibits a quorum cell population threshold that determines if immune responses develop on activation. We determine the analytic formulas of cell proliferation thresholds that allow us to study the sensibility of the quorum growth thresholds controlling immune responses.
dc.identifier.citationBurroughs, N. J., Oliveira, B. M. P. M., Pinto, A. A., & Ferreira, M. (2011). Immune response dynamics. Mathematical and Computer Modelling of Dynamical Systems, 53(7-8), 1410-1419. https://doi.org/10.1016/j.mcm.2010.02.040. Repositório Institucional UPT. https://hdl.handle.net/11328/6334
dc.identifier.issn1387-3954
dc.identifier.issn1744-5051
dc.identifier.urihttps://hdl.handle.net/11328/6334
dc.language.isoeng
dc.publisherElsevier
dc.relation.hasversionhttps://doi.org/10.1016/j.mcm.2010.02.040
dc.rightsrestricted access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectImmunology
dc.subjectT cells
dc.subjectTregs
dc.subjectCytokines
dc.subjectSecretion inhibition
dc.subjectGrowth model
dc.subjectODE model
dc.subject.fosCiências Naturais - Ciências da Computação e da Informação
dc.titleImmune response dynamics
dc.typejournal article
dcterms.referenceshttps://www.sciencedirect.com/science/article/pii/S0895717710001044?via%3Dihub
dspace.entity.typePublication
oaire.citation.endPage1419
oaire.citation.issue7-8
oaire.citation.startPage1410
oaire.citation.titleMathematical and Computer Modelling of Dynamical Systems
oaire.citation.volume53
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.affiliation.nameREMIT – Research on Economics, Management and Information Technologies
person.familyNameFerreira
person.givenNameMiguel
person.identifier.ciencia-id7312-2245-4991
person.identifier.orcid0000-0003-0570-6259
person.identifier.scopus-author-id55860403900
relation.isAuthorOfPublicationdc7dc958-bfcb-4cae-b0e1-279ba1e6b352
relation.isAuthorOfPublication.latestForDiscoverydc7dc958-bfcb-4cae-b0e1-279ba1e6b352

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