Immune response dynamics

Abstract

The consequences of regulatory cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We determine the analytic formula that describes the fine balance between Regulatory cells and cells at controlled and immune response equilibrium states. We demonstrate that cytokine dependent growth exhibits a quorum cell population threshold that determines if immune responses develop on activation. We determine the analytic formulas of cell proliferation thresholds that allow us to study the sensibility of the quorum growth thresholds controlling immune responses.