Conde, Ana
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Conde
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Ana
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Ana Conde
Biography
Ana Conde é atualmente Professora Associada e coordenadora do Doutoramento em Psicologia Clínica e Aconselhamento no Departamento de Psicologia e Educação da Universidade Portucalense. Ao longo das últimas décadas tem investigado as trajetórias de desenvolvimento de mães, pais e bebés ao longo da gravidez e após o parto, com especial foco na análise dos processos biológicos e psicológicos implicados no exercício da parentalidade e na explicação do impacto da saúde mental perinatal dos pais no desenvolvimento socioemocional das crianças nos primeiros anos de vida.
Afiliação:
I2P - Instituto Portucalense de Psicologia.
DPE - Departamento de Psicologia e Educação.
1619-AA8A-C8CA
24070037400
AIA-1756-2022Research Projects
Organizational Units
CINTESIS.UPT - Centro de Investigação em Tecnologias e Serviços de Saúde
Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS.UPT), former I2P, is an R&D unit devoted to the study of cognition and behaviour in context. With an interdisciplinary focus, namely on Education, Translational and Applied Psychology
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Publication Open Access Inflammatory biomarkers and perinatal depression: A systematic review2024-05-31 - Silva-Fernandes, Anabela; Marques, Margarida; Caparros-Gonzalez, Rafael; Fransson, Emma; Mesquita, Ana; Figueiredo, Bárbara; Skalkidou, Alkistis; Conde, AnaBackground Approximately 10 to 20% of pregnant women worldwide experience perinatal depression (PND), a depressive episode with onset during pregnancy or after childbirth. We performed a systematic review to identify, summarize and discuss studies on inflammatory biomarkers described in relation to PND. Method Inclusion criteria defined the selection of observational studies written in English, French, Spanish or Portuguese, that evaluate analytical levels of inflammatory molecules (protein levels) in biological fluids in women, with a diagnosis of depression using ICD/DSM diagnostic criteria or depressive symptoms assessed by standardized psychometric instruments, during pregnancy and/or postpartum. Case reports, experimental studies, reviews, qualitative analysis, meta-analysis, gray literature or replicated data were excluded. Three electronic databases were used for search (Pubmed, Web of Science and PsychInfo) and quality assessment of selected studies were performed using the Newcastle-Ottawa Scale. Data extraction included study design; number of subjects; obstetric information; tools and timepoints of depression and inflammatory markers assessment. Results 56 studies (sample size for cross-sectional and case-control studies ranging from 10 to 469; sample size for longitudinal studies ranging from 26 to 467), where the major aim was to analyze the association between depression and inflammatory biomarkers during pregnancy and postpartum period were included in this systematic review. Overall, the findings of our systematic review lend support to the hypothesis that several inflammatory markers may be associated with peripartum depressive symptoms. The associations were somewhat different looking at pregnancy compared to the delivery time-point and postpartum, and mainly referred to increased levels of IL-6, IL-8, CRP and TNF-α among depressed. Discussion In summary, our systematic review findings provide evidence supporting the hypothesis that several inflammatory markers may correlate with peripartum depressive symptoms. However, our work also highlighted notable differences in the timing of biological sampling for inflammatory markers and in the methodologies used to assess depression during the perinatal period. Additionally, variations were observed in how inflammatory biomarkers and depression were approached, including their classification as exposure or outcome variables, and the timing of assessments. It is essential for future research to investigate the influence of biological fluids and the timing of assessments for both inflammatory biomarkers and depression to gain a deeper understanding of their association. This comprehensive exploration is pivotal for elucidating the intricate relationship between inflammation and perinatal depression.Publication Open Access Efficacy and safety of TMS and tDCS in memory deficits Alzheimer's disease2024-06-01 - Mendes, Augusto J.; Rocha, Magda; Rodrigues, Pedro F. S.; Fernandes, Sara M.; Conde, Ana; Leite, JorgeTranscranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) are promising non-pharmacological therapeutic options for Alzheimer’s´ Disease (AD). The aim of this meta-analysis is to assess which intervention (i.e., TMS or tDCS) is more effective for memory losses in people with AD. As secondary outcome, safety will be addressed. [...]Publication Open Access Mother’s anxiety and depression during the third pregnancy trimester and neonate’s mother versus stranger’s face/voice visual preference.2010-08-01 - Figueiredo, Bárbara; Pacheco, Alexandra; Costa, Raquel; Teixeira, César; Conde, AnaPublication Open Access Maternal coffe intake and associated risk factors: effects on fetal growth and activity2011-04-01 - Teves, Cláudia; Figueiredo, Bárbara; Conde, AnaEmpirical studies have shown that fetal growth and activity can be affected by several risk factors, such as maternal anxiety, depression and tobacco or alcohol consumption. Caffeine intake has received less attention in the literature, as well as the analysis of the mutual interplay of the range of such risk factors. This study aimed to examine effects of mother's coffee intake and associated risk factors during early pregnancy on fetal growth and activity. The sample involved 47 fetuses (51.1% male and 48.9% female) with gestational ages between 20-22 weeks whose mothers were recruited in a Portuguese antenatal obstetric unit. Repeated measures of mother's anxiety (STAI-S) and depression (EPDS) and information about socio-demographics and substances consumption were collected during the first and second trimesters of pregnancy. Fetal activity and biometry were measured during the 2(nd) trimester ultrasound. Results showed that 1) 23.4% of the pregnant women (N = 11) had regular coffee intake; 2) no significant differences were found neither on fetal growth nor on fetal movements considering mother's coffee intake; 3) when mother's socio-demographics and substances consumption were considered, tobacco consumption and anxiety at the 2(nd) trimester appeared as significant predictors of fetal growth and mother's coffee intake and anxiety symptoms at the 2(nd) trimester emerged as significant predictors of fetal movements. An adverse impact of maternal coffee intake during pregnancy was found on fetal activity but not on fetal growth. A deeper understanding of the multiple pathways by which these risk factors affect fetal growth and activity is needed.Publication Open Access Ansiedade na gravidez: factores de risco e implicações para a saúde e bem-estar da mãe2003-01-01 - Figueiredo, Bárbara; Conde, AnaO presente artigo é uma revisão da investigação mais relevante no domínio da ansiedade durante a gravidez. Apresenta os resultados dos estudos que apontam para a existência de um grande número de mulheres com níveis significativos de sintomatologia ansiosa durante a gestação, independentemente do seu carácter patológico. Aborda um conjunto de factores que podem ser considerados de risco para a presença de níveis elevados de ansiedade durante a gravidez e analisa as suas principais consequências e implicações para a saúde e bem-estar da mulher. Finaliza, alertando para a necessidade de implementar medidas de prevenção e intervenção em situações de alta ansiedade, as quais são fundamentais para garantir uma adequada prestação de cuidados à mulher grávida, assim como para reduzir a incidência de complicações obstétricas. The present article is a review of the most relevant and recent research about anxiety in pregnancy. The results presented indicate that there is a very large number of women who show high levels of anxiety during childbearing, independently of its pathological character. This article also considers several risk factors for the mother's high levels of anxiety during pregnancy, and analyses its main consequences and implications for her own health and well-being. This review ends alerting to the need of improving preventive and interventive measures for reducing the high anxiety levels of pregnant women, in order to provide adequate cure, as to diminish the morbidity and the obstetrical complications that may occur.Publication Open Access Impact of prenatal depressive symptoms on postpartum depressive symptoms: Mediation effect of perinatal health2018 - Silva, Fábio; Costa, Raquel; Conde, AnaTo analyze the mediation effect of perinatal health on the association between prenatal depressive symptoms and postpartum depressive symptoms 180 women filled the Edinburgh Postnatal Depressive Scale (EPDS) at 35 weeks of gestation and two months after childbirth. Perinatal health data was collected during the first 4 days after childbirth, using the Optimality Index. 25.6% of the mothers-to-be presented clinically significant depressive symptoms, and of these, 80.4% still show clinically significant depressive symptoms at 2-months postpartum. Prenatal depressive symptoms predict higher postpartum depressive symptoms. Additionally, results also showed that the effect of prenatal depressive symptoms on postnatal depressive symptoms is not mediated by perinatal health. Mothers-to-be with prenatal depressive symptoms seem to be at risk for postnatal depression, even when perinatal health is not compromised. This highlights the importance of early screening of prenatal depressive symptoms in order to promote an early intervention on women’s mental health, leading to a better transition to parenthood and to a decrease of the burden of this public health problem on children and families.Publication Open Access Brazelton neonatal behavioral assessment scale: a psychometric study in portuguese sample2010 - Costa, Raquel; Figueiredo, Bárbara; Tendais, Iva; Pacheco, Alexandra; Conde, AnaPublication Open Access Efficacy and safety of repetitive transcranial magnetic stimulation and transcranial direct current stimulation in memory deficits in patients with Alzheimer's disease: Meta-analysis and systematic review2024-03-01 - Mendes, Augusto J.; Leite, Jorge; Fernandes, Sara M.; Rodrigues, Pedro F. S.; Conde, Ana; Rocha, MagdaRepetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are two of the most used non-pharmacological interventions for Alzheimer's Disease (AD). However, most of the clinical trials have focused on evaluating the effects on global cognition and not on specific cognitive functions. Therefore, considering that memory loss is one of the hallmark symptoms of AD, we aim to assess the efficacy and safety of tDCS and rTMS in memory deficits. For that, multilevel random effect models were performed considering the standardized mean difference (SMD) between active and sham stimulation. A total of 19 studies with 411 participants demonstrated positive effects in memory after tDCS (SMD=0.20, p = 0.04) and rTMS (SMD=0.44, p = 0.001). Subgroup analysis revealed that tDCS had greater efficacy when administered in temporal regions (SMD=0.32, p = 0.04), whereas rTMS was superior when applied in frontal regions (SMD=0.61, p < 0.001). Therefore, depending on the brain region of stimulation, both interventions produced a positive effect on memory symptoms in AD patients. Finally, the safety of both techniques was observed in the AD population after the reporting of almost no serious events.Publication Open Access Screening for depression and anxiety disorders from pregnancy to postpartum with the EPDS and STAI.2014 - Tendais, Iva; Costa, Raquel; Figueiredo, Bárbara; Conde, AnaThe Edinburgh Postnatal Depression Scale (EPDS) and the State Anxiety Inventory (STAI-S) are widely used self-report measures that still need to be further validated for the perinatal period. The aim of this study was to examine the screening performance of the EPDS and the STAI-S in detecting depressive and anxiety disorders at pregnancy and postpartum. Women screening positive on EPDS (EPDS ≥ 9) or STAI-S (STAI-S ≥ 45) during pregnancy (n = 90), as well as matched controls (n = 58) were selected from a larger study. At 3 months postpartum, 99 of these women were reassessed. At a second stage, women were administered a clinical interview to establish a DSM-IV-TR diagnosis. Receiver operator characteristics (ROC) analysis yielded areas under the curve higher than .80 and .70 for EPDS and STAI-S, respectively. EPDS and STAI-S optimal cut-offs were found to be lower at postpartum (EDPS = 7; STAI-S = 34) than during pregnancy (EPDS = 9; STAI-S = 40). EPDS and STAI-S are reasonably valid screening tools during pregnancy and the postpartum.Publication Open Access Attachment style and psychological adjustment in couples2011 - Figueiredo, Bárbara; Bifulco, Antonia; Conde, AnaThe present study addresses the gap in research concerning poor marital support together with insecure attachment style explaining risk for anxiety or depression in both members of a couple expecting a baby. The Attachment Style Interview (ASI) was administered separately to both members of a couple (N ¼ 126) during the second trimester of pregnancy together with measures of state-anxiety (STAI-S) and depression (EPDS). These measures were repeated at three months postpartum. While insecure attachment style was related to higher anxiety and depression symptoms in both partners at both time periods, there was an increase of postnatal depression symptoms in women. Poor partner support contributed to anxiety symptoms only in men. When insecure attachment combinations in both members of the couple were examined, insecure styles increased anxiety and depression symptoms in both genders antenatally, but postnatal anxiety symptoms only in women. A combined effect of partner’s support and attachment style on temporal changes of anxiety symptoms was observed differently for women and men. It is important to assess attachment style and partner support of both members, as well as the mutual interplay between them, to understand gendered differences in psychological adjustment of a couple expecting a baby.