Working memory training coupled with transcranial direct current stimulation in older adults: A randomized controlled experiment

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dc.contributor.authorTeixeira-Santos, Ana C.
dc.contributor.authorMoreira, Célia S.
dc.contributor.authorPereira, Diana R.
dc.contributor.authorPinal, Diego
dc.contributor.authorFregni, Felipe
dc.contributor.authorCarvalho, Sandra
dc.contributor.authorSampaio, Adriana
dc.contributor.authorLeite, Jorge
dc.date.accessioned2022-09-09T16:43:55Z
dc.date.available2022-09-09T16:43:55Z
dc.date.issued2022-04-12
dc.description.abstractBackground: Transcranial direct current stimulation (tDCS) has been employed to boost working memory training (WMT) effects. Nevertheless, there is limited evidence on the efficacy of this combination in older adults. The present study is aimed to assess the delayed transfer effects of tDCS coupled with WMT in older adults in a 15-day follow-up. We explored if general cognitive ability, age, and educational level predicted the effects. Methods: In this single-center, double-blind randomized sham-controlled experiment, 54 older adults were randomized into three groups: anodal-tDCS (atDCS)+WMT, sham-tDCS (stDCS)+WMT, and double-sham. Five sessions of tDCS (2 mA) were applied over the left dorsolateral prefrontal cortex (DLPFC). Far transfer was measured by Raven’s Advanced Progressive Matrices (RAPM), while the near transfer effects were assessed through Digit Span. A frequentist linear mixed model (LMM) was complemented by a Bayesian approach in data analysis. Results: Working memory training improved dual n-back performance in both groups submitted to this intervention but only the group that received atDCS+WMT displayed a significant improvement from pretest to follow-up in transfer measures of reasoning (RAPM) and short-term memory (forward Digit Span). Near transfer improvements predicted gains in far transfer, demonstrating that the far transfer is due to an improvement in the trained construct of working memory. Age, formal education, and vocabulary score seem to predict the gains in reasoning. However, Bayesian results do not provide substantial evidence to support this claim. Conclusion: This study will help to consolidate the incipient but auspicious field of cognitive training coupled with tDCS in healthy older adults. Our findings demonstrated that atDCS may potentialize WMT by promoting transfer effects in short-term memory and reasoning in older adults, which are observed especially at follow-up.pt_PT
dc.identifier.citationTeixeira-Santos, A. C., Moreira, C. S., Pereira, D. R., Pinal, D., Fregni, F., Leite, J., Carvalho, S., & Sampaio, A. (2022). Working memory training coupled with transcranial direct current stimulation in older adults: A randomized controlled experiment. Frontiers in Aging Neuroscience, 14(Article ID 827188), 1-14. https://doi.org/10.3389/fnagi.2022.827188. Repositório Institucional UPT. http://hdl.handle.net/11328/4458pt_PT
dc.identifier.doihttps://doi.org/10.3389/fnagi.2022.827188pt_PT
dc.identifier.issn1663-4365 (Electronic)
dc.identifier.urihttp://hdl.handle.net/11328/4458
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Media SA.pt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fnagi.2022.827188/fullpt_PT
dc.rightsopen accesspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjecttDCSpt_PT
dc.subjectCognitive trainingpt_PT
dc.subjectWorking memorypt_PT
dc.subjectNeuroplasticitypt_PT
dc.subjectOlder adultspt_PT
dc.subjectReasoningpt_PT
dc.subjectTransfer effectspt_PT
dc.titleWorking memory training coupled with transcranial direct current stimulation in older adults: A randomized controlled experimentpt_PT
dc.typejournal articlept_PT
degois.publication.firstPage1pt_PT
degois.publication.issueArticle ID 827188pt_PT
degois.publication.lastPage14pt_PT
degois.publication.titleFrontiers in Aging Neurosciencept_PT
degois.publication.volume14pt_PT
dspace.entity.typePublicationen
person.affiliation.nameI2P - Instituto Portucalense de Psicologia
person.familyNameLeite
person.givenNameJorge
person.identifier.ciencia-idA71F-2404-41CE
person.identifier.gsid03piNtgAAAAJ
person.identifier.orcid0000-0002-0323-9012
person.identifier.ridE-4404-2013
person.identifier.scopus-author-id47761976700
relation.isAuthorOfPublication9dc1f0ec-b563-4cf4-b876-aafc02d0db23
relation.isAuthorOfPublication.latestForDiscovery9dc1f0ec-b563-4cf4-b876-aafc02d0db23

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