Association study of variants in genes FTO, SLC6A4, DRD2, BDNF and GHRL with Binge Eating Disorder (BED) in Portuguese women
Date
2019-03
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Advisor
Coadvisor
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Volume Title
Publisher
Elsevier
Language
English
Alternative Title
Abstract
A population based case-control study was conducted in Portuguese women with overweight/obesity to investigate the possible association of variants in genes FTO, SLC6A4, DRD2, BDNF and GHRL with binge eating disorder (BED). The distribution of seven polymorphisms was evaluated in 31 BED patients and 62 controls. No significant associations were found between polymorphisms and BED. Of interest, a markedly lower frequency of the FTO rs9939609 obesity risk A-allele was found in BED patients (0.290) in relation to the control group (0.402). Contrasting with anorexia nervosa and bulimia nervosa, our data suggest that rs9939609 A-allele has no potential role in BED.
Keywords
BED genetic susceptibility, FTO rs9939609 polymorphism, Obesity
Document Type
Journal article
Publisher Version
DOI: 10.1016/j.psychres.2019.01.047
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Citation
Palmeira, L., Cunha, M., Padez, C., Alvarez, M., Pinto-Gouveia, J., & Manco, L. (2019). Association study of variants in genes FTO, SLC6A4, DRD2, BDNF and GHRL with binge eating disorder (BED) in Portuguese women. Psychiatry Research, 273, 309-311. Doi: 10.1016/j.psychres.2019.01.047. Disponível no Repositório UPT, http://hdl.handle.net/11328/3506
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Access Type
Open Access