Tailoring transcranial alternating current stimulation based on endogenous event-related P3 to modulate premature responses: A feasibility study

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dc.contributor.authorMendes, Augusto
dc.contributor.authorLema, Alberto
dc.contributor.authorCarvalho, Sandra
dc.contributor.authorLeite, Jorge
dc.date.accessioned2024-04-04T15:18:48Z
dc.date.available2024-04-04T15:18:48Z
dc.date.issued2024-04-03
dc.description.abstractBackground Transcranial alternating current stimulation (tACS) is a brain stimulation method for modulating ongoing endogenous oscillatory activity at specified frequency during sensory and cognitive processes. Given the overlap between event-related potentials (ERPs) and event-related oscillations (EROs), ERPs can be studied as putative biomarkers of the effects of tACS in the brain during cognitive/sensory task performance. Objective This preliminary study aimed to test the feasibility of individually tailored tACS based on individual P3 (latency and frequency) elicited during a cued premature response task. Thus, tACS frequency was individually tailored to match target-P3 ERO for each participant. Likewise, the target onset in the task was adjusted to match the tACS phase and target-P3 latency. Methods Twelve healthy volunteers underwent tACS in two separate sessions while performing a premature response task. Target-P3 latency and ERO were calculated in a baseline block during the first session to allow a posterior synchronization between the tACS and the endogenous oscillatory activity. The cue and target-P3 amplitudes, delta/theta ERO, and power spectral density (PSD) were evaluated pre and post-tACS blocks. Results Target-P3 amplitude significantly increased after activetACS, when compared to sham. Evoked-delta during cue-P3 was decreased after tACS. No effects were found for delta ERO during target-P3 nor for the PSD and behavioral outcomes. Conclusion The present findings highlight the possible effect of phase synchronization between individualized tACS parameters and endogenous oscillatory activity, which may result in an enhancement of the underlying process (i.e., an increase of target-P3). However, an unsuccessful synchronization between tACS and EEG activity might also result in a decrease in the evoked-delta activity during cue-P3. Further studies are needed to optimize the parameters of endogenous activity and tACS synchronization. The implications of the current results for future studies, including clinical studies, are further discussed since transcranial alternating current stimulation can be individually tailored based on endogenous event-related P3 to modulate responses.
dc.identifier.citationMendes, A. J., Lema, A., Carvalho, S., & Leite, J. (2024). Tailoring transcranial alternating current stimulation based on endogenous event-related P3 to modulate premature responses: a feasibility study. PeerJ Life & Environment, 12, e17144. https://doi.org/10.7717/peerj.17144. Repositório Institucional UPT. https://hdl.handle.net/11328/5566
dc.identifier.issn21678359
dc.identifier.urihttps://hdl.handle.net/11328/5566
dc.language.isoeng
dc.publisherPeerJ
dc.relation.hasversionhttps://doi.org/10.7717/peerj.17144
dc.rightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectWaiting Impulsivity
dc.subjectPremature responses
dc.subjecttACS
dc.subjectP3
dc.subjectDelta
dc.subjectTheta
dc.subject.fosCiências Sociais - Psicologia
dc.subject.ods03 - good health and well-being
dc.titleTailoring transcranial alternating current stimulation based on endogenous event-related P3 to modulate premature responses: A feasibility study
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPagee17144
oaire.citation.titlePeerJ Life & Environment
oaire.citation.volume12
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.affiliation.nameI2P - Instituto Portucalense de Psicologia
person.familyNameLeite
person.givenNameJorge
person.identifier.ciencia-idA71F-2404-41CE
person.identifier.gsid03piNtgAAAAJ
person.identifier.orcid0000-0002-0323-9012
person.identifier.ridE-4404-2013
person.identifier.scopus-author-id47761976700
relation.isAuthorOfPublication9dc1f0ec-b563-4cf4-b876-aafc02d0db23
relation.isAuthorOfPublication.latestForDiscovery9dc1f0ec-b563-4cf4-b876-aafc02d0db23

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