Cognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: A randomized clinical trial

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dc.contributor.authorSantos, Vinicius Souza dos Souza dos
dc.contributor.authorZortea, Maxciel
dc.contributor.authorAlves, Rael Lopes
dc.contributor.authorNaziazeno, Cátia Cilene dos Santos
dc.contributor.authorSaldanha, Júlia Schirmer
dc.contributor.authorCarvalho, Sandra da Conceição Ribeiro
dc.contributor.authorTorres, Iraci Lucena da Silva
dc.contributor.authorSouza, Andressa
dc.contributor.authorCalvetti, Prisla Ücker
dc.contributor.authorFregni, Felipe
dc.contributor.authorCaumo, Wolnei
dc.contributor.authorLeite, Jorge
dc.date.accessioned2019-09-06T11:00:43Z
dc.date.available2019-09-06T11:00:43Z
dc.date.issued2018-08-20
dc.description.abstractCognitive dysfunction in fibromyalgia has been reported, especially memory. Anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been effective in enhancing this function. We tested the effects of eight sessions of tDCS and cognitive training on immediate and delayed memory, verbal fluency and working memory and its association with brain-derived neurotrophic factor (BDNF) levels. Forty females with fibromyalgia were randomized to receive eight sessions of active or sham tDCS. Anodal stimulation (2 mA) was applied over the DLPFC and online combined with a working memory training (WMT) for 20 minutes. Pre and post-treatment neurocognitive tests were administered. Data analysis on deltas considering years of education and BDNF as covariates, indicated active-tDCS + WMT significantly increased immediate memory indexed by Rey Auditory Verbal Learning Test score when compared to sham. This effect was dependent on basal BDNF levels. In addition, the model showed active stimulation increased orthographic and semantic verbal fluency scores (Controlled Oral Word Association Test) and short-term memory (Forward Digit Span). The combination of both techniques seemed to produce effects on specific cognitive functions related to short-term and long-term episodic memory and executive functions, which has clinical relevance for top-down treatment approaches in FM.
dc.identifier.citationSantos, V. S. S., Zortea, M., Alves, R. L., Naziazeno, C. C. S., Saldanha, J. S., Carvalho, S. C. R. ...Caumo, W. (2018). Cognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: A randomized clinical trial. Scientific Reports, 8, 12477, 1-11. doi:10.1038/s41598-018-30127-z.Disponível no Repositório UPT, http://hdl.handle.net/11328/2882
dc.identifier.doi10.1038/s41598-018-30127-zpt_PT
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11328/2882
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-018-30127-z
dc.rightsopen accesspt_PT
dc.titleCognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: A randomized clinical trialpt_PT
dc.typejournal articlept_PT
dspace.entity.typePublicationen
person.affiliation.nameI2P - Instituto Portucalense de Psicologia
person.familyNameLeite
person.givenNameJorge
person.identifier.ciencia-idA71F-2404-41CE
person.identifier.gsid03piNtgAAAAJ
person.identifier.orcid0000-0002-0323-9012
person.identifier.ridE-4404-2013
person.identifier.scopus-author-id47761976700
relation.isAuthorOfPublication9dc1f0ec-b563-4cf4-b876-aafc02d0db23
relation.isAuthorOfPublication.latestForDiscovery9dc1f0ec-b563-4cf4-b876-aafc02d0db23

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