Efficacy and safety of repetitive transcranial magnetic stimulation and transcranial direct current stimulation in memory deficits in patients with Alzheimer's disease: Meta-analysis and systematic review

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dc.contributor.authorMendes, Augusto J.
dc.contributor.authorLeite, Jorge
dc.contributor.authorFernandes, Sara M.
dc.contributor.authorRodrigues, Pedro F. S.
dc.contributor.authorConde, Ana
dc.contributor.authorRocha, Magda
dc.date.accessioned2024-04-04T15:03:42Z
dc.date.available2024-04-04T15:03:42Z
dc.date.issued2024-03-01
dc.description.abstractRepetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are two of the most used non-pharmacological interventions for Alzheimer's Disease (AD). However, most of the clinical trials have focused on evaluating the effects on global cognition and not on specific cognitive functions. Therefore, considering that memory loss is one of the hallmark symptoms of AD, we aim to assess the efficacy and safety of tDCS and rTMS in memory deficits. For that, multilevel random effect models were performed considering the standardized mean difference (SMD) between active and sham stimulation. A total of 19 studies with 411 participants demonstrated positive effects in memory after tDCS (SMD=0.20, p = 0.04) and rTMS (SMD=0.44, p = 0.001). Subgroup analysis revealed that tDCS had greater efficacy when administered in temporal regions (SMD=0.32, p = 0.04), whereas rTMS was superior when applied in frontal regions (SMD=0.61, p < 0.001). Therefore, depending on the brain region of stimulation, both interventions produced a positive effect on memory symptoms in AD patients. Finally, the safety of both techniques was observed in the AD population after the reporting of almost no serious events.
dc.identifier.citationFernandes, S. M., Mendes, A. J., Rodrigues, P. F. S., Conde, A., Rocha, M., & Leite, J. (2024). Efficacy and safety of repetitive transcranial magnetic stimulation and transcranial direct current stimulation in memory deficits in patients with Alzheimer's disease: Meta-analysis and systematic review. International Journal of Clinical and Health Psychology (IJCHP), 24(2), 100452, 1-17. https://doi.org/10.1016/j.ijchp.2024.100452. Repositório Institucional UPT. https://hdl.handle.net/11328/5565
dc.identifier.issn1697-2600
dc.identifier.urihttps://hdl.handle.net/11328/5565
dc.language.isoeng
dc.publisherElsevier
dc.relation.hasversionhttps://doi.org/10.1016/j.ijchp.2024.100452
dc.rightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAD
dc.subjectAlzheimer
dc.subjectMemory
dc.subjectrTMS
dc.subjecttDCS.
dc.subject.fosCiências Sociais - Psicologia
dc.subject.ods03 - good health and well-being
dc.titleEfficacy and safety of repetitive transcranial magnetic stimulation and transcranial direct current stimulation in memory deficits in patients with Alzheimer's disease: Meta-analysis and systematic review
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2
oaire.citation.startPage100452
oaire.citation.titleInternational Journal of Clinical and Health Psychology
oaire.citation.volume24
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.affiliation.nameI2P - Instituto Portucalense de Psicologia
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