Speed of Processing (SoP) Training Plus α-tACS in people with mild cognitive impairment: a double blind, parallel, placebo controlled trial study protocol

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dc.contributor.authorGonçalves, Óscar F.
dc.contributor.authorCarvalho, Sandra
dc.contributor.authorLeite, Jorge
dc.date.accessioned2023-08-31T15:14:29Z
dc.date.available2023-08-31T15:14:29Z
dc.date.issued2022-07-14
dc.description.abstractSeveral cognitive training programs, alone or in combination with non-invasive brain stimulation have been tested in order to ameliorate age-related cognitive impairments, such as the ones found in Mild Cognitive Impairment (MCI). However, the effects of Cognitive Training (CT)—combined or not—with several forms of non-invasive brain stimulation have been modest at most. We aim to assess if Speed of Processing (SoP) training combined with alpha transcranial alternating current stimulation (a-tACS) is able to increase speed of processing as assessed by the Useful Field of View (UFOV), when comparing to SoP training or active a-tACS alone. Moreover, we want to assess if those changes in speed of processing transfer to other cognitive domains, such as memory, language and executive functioning by using the NIH EXAMINER. We also want to test the mechanisms underlying these interventions, namely brain connectivity and coherence as assessed by electroencephalography (EEG). To that purpose, our proposal is to enroll 327 elders diagnosed with MCI in a double-blinded, parallel randomized clinical trial assessing the effects of combining SoP with alpha endogenous tACS (either active or sham) in people with MCI. Participants will perform an intervention that will last for 15 sessions. For the first 3 weeks, participants will receive nine sessions of the intervention, and then will receive two sessions per week (i.e., booster) for the following 3 weeks. They will then be assessed at 1, 3, and 6 months after the intervention has ended. This will allow us to detect the immediate, and long-term effects of the interventions, as well as to probe the mechanisms underlying its effects.pt_PT
dc.identifier.citationLeite, J., Gonçalves, Ó. F., & Carvalho, S. (2022). Speed of Processing (SoP) Training Plus α-tACS in people with mild cognitive impairment: a double blind, parallel, placebo controlled trial study protocol. Frontiers in Aging Neuroscience, 14, pp. 1-10. Repositório Institucional UPT. http://hdl.handle.net/11328/5054pt_PT
dc.identifier.doi10.3389/fnagi.2022.880510pt_PT
dc.identifier.issn1663-4365
dc.identifier.urihttp://hdl.handle.net/11328/5054
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.rightsopen accesspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjecttACS (transcranial alternating current stimulation)pt_PT
dc.subjectCognitive trainingpt_PT
dc.subjectMCI (mild cognitive impairment)pt_PT
dc.subjectNIBS and cognitionpt_PT
dc.subjectEEGpt_PT
dc.titleSpeed of Processing (SoP) Training Plus α-tACS in people with mild cognitive impairment: a double blind, parallel, placebo controlled trial study protocolpt_PT
dc.typejournal articlept_PT
degois.publication.firstPage1pt_PT
degois.publication.lastPage10pt_PT
degois.publication.titleFrontiers in Aging Neurosciencept_PT
degois.publication.volume14pt_PT
dspace.entity.typePublicationen
person.affiliation.nameI2P - Instituto Portucalense de Psicologia
person.familyNameLeite
person.givenNameJorge
person.identifier.ciencia-idA71F-2404-41CE
person.identifier.gsid03piNtgAAAAJ
person.identifier.orcid0000-0002-0323-9012
person.identifier.ridE-4404-2013
person.identifier.scopus-author-id47761976700
relation.isAuthorOfPublication9dc1f0ec-b563-4cf4-b876-aafc02d0db23
relation.isAuthorOfPublication.latestForDiscovery9dc1f0ec-b563-4cf4-b876-aafc02d0db23

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