Digitalized transcranial electrical stimulation: a consensus statement

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dc.contributor.authorBrunoni, André R.
dc.contributor.authorEkhtiari, Hamed
dc.contributor.authorAntal, Andrea
dc.contributor.authorAuvichayapat, Paradee
dc.contributor.authorBaeken, Chris
dc.contributor.authorBenseñor, Isabela M
dc.contributor.authorBikson, Marom
dc.contributor.authorBoggio, Paulo
dc.contributor.authorBorroni, Barbara
dc.contributor.authorBrighina, Filippo
dc.contributor.authorBrunelin, Erome
dc.contributor.authorCarvalho, Sandra
dc.contributor.authorCaumo, Wolnei
dc.contributor.authorCiechanski, Patrick
dc.contributor.authorCharvet, Leigh
dc.contributor.authorClark, Vincent P
dc.contributor.authorKadosh, Roi Cohen
dc.contributor.authorCotelli, Maria
dc.contributor.authorDatta, Abhishek
dc.contributor.authorDeng, Zhi-De
dc.contributor.authorRaedt, Rudi De
dc.contributor.authorRidder, Dirk De
dc.contributor.authorFitzgerald, Paul B
dc.contributor.authorFloel, Agnes
dc.contributor.authorFrohlich, Flavio
dc.contributor.authorGeorge, Mark S
dc.contributor.authorGhobadi-Azbari, Peyman
dc.contributor.authorGoerigk, Stephan
dc.contributor.authorHamilton, Roy H
dc.contributor.authorJaberzadeh, Shapour J
dc.contributor.authorHoy, Kate
dc.contributor.authorKidgell, Dawson J
dc.contributor.authorZonoozi, Arash Khojasteh
dc.contributor.authorKirton, Adam
dc.contributor.authorLaureys, Steven
dc.contributor.authorLavidor, Michal
dc.contributor.authorLee, Kiwon
dc.contributor.authorLisanby, Sarah H
dc.contributor.authorLoo, Colleen
dc.contributor.authorMartin, Donel M
dc.contributor.authorMiniussi, Carlo
dc.contributor.authorMondino, Marine
dc.contributor.authorMonte-Silva, Katia
dc.contributor.authorMorales-Quezada, Leon
dc.contributor.authorNitsche, Michael A
dc.contributor.authorOkano, Alexandre H
dc.contributor.authorOliveira, Claudia S
dc.contributor.authorOnarheim, Balder
dc.contributor.authorPacheco-Barrios, Kevin
dc.contributor.authorPadberg, Frank
dc.contributor.authorNakamura-Palacios, Ester M
dc.contributor.authorPalm, Ulrich
dc.contributor.authorPaulus, Walter
dc.contributor.authorPlewnia, Christian
dc.contributor.authorPriori, Alberto
dc.contributor.authorRajji, Tarek K
dc.contributor.authorRazza, Lais B
dc.contributor.authorRehn, Erik M
dc.contributor.authorRuffini, Giuliov
dc.contributor.authorSchellhorn, Klaus
dc.contributor.authorZare-Bidoky, Mehran
dc.contributor.authorSimis, Marcel
dc.contributor.authorSkorupinski, Pawel
dc.contributor.authorSuen, Paulo
dc.contributor.authorThibaut, Aurore
dc.contributor.authorValiengo, Leandro C L
dc.contributor.authorVanderhasselt, Marie-Anne
dc.contributor.authorVanneste, Sven
dc.contributor.authorVenkatasubramanian, Ganesan
dc.contributor.authorViolante, Ines R
dc.contributor.authorWexler, Anna
dc.contributor.authorWoods, Adam J
dc.contributor.authorFregni, Felipe
dc.contributor.authorLeite, Jorge
dc.date.accessioned2023-08-31T16:00:52Z
dc.date.available2023-08-31T16:00:52Z
dc.date.issued2022-09-05
dc.description.abstractObjective: Although relatively costly and non-scalable, non-invasive neuromodulation interventions are treatment alternatives for neuropsychiatric disorders. The recent developments of highly-deployable transcranial electric stimulation (tES) systems, combined with mobile-Health technologies, could be incorporated in digital trials to overcome methodological barriers and increase equity of access. The study aims are to discuss the implementation of tES digital trials by performing a systematic scoping review and strategic process mapping, evaluate methodological aspects of tES digital trial designs, and provide Delphi-based recommendations for implementing digital trials using tES. Methods: We convened 61 highly-productive specialists and contacted 8 tES companies to assess 71 issues related to tES digitalization readiness, and processes, barriers, advantages, and opportunities for implementing tES digital trials. Delphi-based recommendations (>60% agreement) were provided. Results: The main strengths/opportunities of tES were: (i) non-pharmacological nature (92% of agreement), safety of these techniques (80%), affordability (88%), and potential scalability (78%). As for weaknesses/ threats, we listed insufficient supervision (76%) and unclear regulatory status (69%). Many issues related to methodological biases did not reach consensus. Device appraisal showed moderate digitalization readiness, with high safety and potential for trial implementation, but low connectivity. Conclusions: Panelists recognized the potential of tES for scalability, generalizability, and leverage of digital trials processes; with no consensus about aspects regarding methodological biases. Significance: We further propose and discuss a conceptual framework for exploiting shared aspects between mobile-Health tES technologies with digital trials methodology to drive future efforts for digitizing tES trials.pt_PT
dc.identifier.citationBrunoni, A., Ekhtiari, H., Antal, A., Auvichayapat, P., Baeken, C., Benseñor, I., Bikson, M., Boggio, P., Borroni, B., Brighina, F., Brunelin, E., Carvalho, S., Caumo, W., Ciechanski, P., Carvet, L., Clark, V., Kadosh, R., Cotelli, M., Datta, A., … Fregni, F. (2022). Digitalized transcranial electrical stimulation: a consensus statement. Clinical Neurophysiology, 143, pp. 154-165. Repositório Institucional UPT. http://hdl.handle.net/11328/5055pt_PT
dc.identifier.doi10.1016/j.clinph.2022.08.018pt_PT
dc.identifier.issn1388-2457
dc.identifier.urihttp://hdl.handle.net/11328/5055
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rightsopen accesspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMobile healthpt_PT
dc.subjectNon-invasive neuromodulationpt_PT
dc.subjectDigital healthpt_PT
dc.subjectSystematic reviewpt_PT
dc.subjectDelphi panelpt_PT
dc.titleDigitalized transcranial electrical stimulation: a consensus statementpt_PT
dc.typejournal articlept_PT
degois.publication.firstPage154pt_PT
degois.publication.lastPage165pt_PT
degois.publication.titleClinical Neurophysiologypt_PT
degois.publication.volume143pt_PT
dspace.entity.typePublicationen
person.affiliation.nameI2P - Instituto Portucalense de Psicologia
person.familyNameLeite
person.givenNameJorge
person.identifier.ciencia-idA71F-2404-41CE
person.identifier.gsid03piNtgAAAAJ
person.identifier.orcid0000-0002-0323-9012
person.identifier.ridE-4404-2013
person.identifier.scopus-author-id47761976700
relation.isAuthorOfPublication9dc1f0ec-b563-4cf4-b876-aafc02d0db23
relation.isAuthorOfPublication.latestForDiscovery9dc1f0ec-b563-4cf4-b876-aafc02d0db23

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