Leite, Jorge
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Leite
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Jorge
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Jorge Leite
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Jorge Leite obtained his PhD in 2011 from the University of Minho, where he also completed his Psychology Degree in 2005. From 2013 to 2016, he underwent postdoctoral training at the Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School. Currently, he holds the positions of Vice-Rector for Research, Associate Professor, and Coordinator of the CINTESIS.UPT. Throughout his career, he has made significant contributions to the field, with over 70 peer-reviewed publications, including articles in journals, book chapters, and conference proceedings. According to Scopus data, over half of his publications are featured in the top 25% of journals, while 45% are among the top 25% most cited documents globally. He has also supervised numerous MSc dissertations and is currently overseeing four PhD theses. Furthermore, he actively participates in various research projects, taking on roles such as Principal Investigator, Researcher, and Supervisor. These projects have successfully secured over 6M euros in funding. His dedication to his work has been recognized with seven awards and/or honors. Furthermore, he has collaborated with 167 fellow researchers in various scientific endeavors.
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RISE-HEALTH@UPT
A RISE-Health tem seis linhas de investigação: Investigação Clínica e Translacional em Ciências Cardiovasculares; Investigação Clínica e Translacional em Oncologia; Investigação Clínica e Translacional em Doenças Inflamatórias e Degenerativas; Política de Saúde, Tecnologia e Transformação Digital; Saúde Comunitária e Desafios Societais.
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Publicação Acesso Aberto Efficacy and safety of repetitive transcranial magnetic stimulation and transcranial direct current stimulation in memory deficits in patients with Alzheimer's disease: Meta-analysis and systematic review2024-03-01 - Mendes, Augusto J.; Leite, Jorge; Fernandes, Sara M.; Rodrigues, Pedro F. S.; Conde, Ana; Rocha, MagdaRepetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are two of the most used non-pharmacological interventions for Alzheimer's Disease (AD). However, most of the clinical trials have focused on evaluating the effects on global cognition and not on specific cognitive functions. Therefore, considering that memory loss is one of the hallmark symptoms of AD, we aim to assess the efficacy and safety of tDCS and rTMS in memory deficits. For that, multilevel random effect models were performed considering the standardized mean difference (SMD) between active and sham stimulation. A total of 19 studies with 411 participants demonstrated positive effects in memory after tDCS (SMD=0.20, p = 0.04) and rTMS (SMD=0.44, p = 0.001). Subgroup analysis revealed that tDCS had greater efficacy when administered in temporal regions (SMD=0.32, p = 0.04), whereas rTMS was superior when applied in frontal regions (SMD=0.61, p < 0.001). Therefore, depending on the brain region of stimulation, both interventions produced a positive effect on memory symptoms in AD patients. Finally, the safety of both techniques was observed in the AD population after the reporting of almost no serious events.Publicação Acesso Aberto Transcranial direct current stimulation decreases P3 amplitude and inherent Delta activity during a waiting impulsivity paradigm: Crossover study2024-02-07 - Mendes, Augusto J.; Galdo-Álvarez, Santiago; Lema, Alberto; Carvalho, Sandra; Leite, JorgeThe inability to wait for a target before initiating an action (i.e., waiting impulsivity) is one of the main features of addictive behaviors. Current interventions for addiction, such as transcranial Direct Current Stimulation (tDCS), have been suggested to improve this inability. Nonetheless, the effects of tDCS on waiting impulsivity and underlying electrophysiological (EEG) markers are still not clear. Therefore, this study aimed to evaluate the effects of neuromodulation over the right inferior frontal gyrus (rIFG) on the behavior and EEG markers of reward anticipation (i.e., cue and target-P3 and underlying delta/theta power) during a premature responding task. For that, forty healthy subjects participated in two experimental sessions, where they received active and sham tDCS over the rIFG combined with EEG recording during the task. To evaluate transfer effects, participants also performed two control tasks to assess delay discounting and motor inhibition. The active tDCS decreased the cue-P3 and target-P3 amplitudes, as well as delta power during target-P3. While no tDCS effects were found for motor inhibition, active tDCS increased the discounting of future rewards when compared to sham. These findings suggest a tDCS-induced modulation of the P3 component and underlying oscillatory activity during waiting impulsivity and the discounting of future rewards.Publicação Acesso Aberto Tailoring transcranial alternating current stimulation based on endogenous event-related P3 to modulate premature responses: A feasibility study2024-04-03 - Mendes, Augusto; Lema, Alberto; Carvalho, Sandra; Leite, JorgeBackground Transcranial alternating current stimulation (tACS) is a brain stimulation method for modulating ongoing endogenous oscillatory activity at specified frequency during sensory and cognitive processes. Given the overlap between event-related potentials (ERPs) and event-related oscillations (EROs), ERPs can be studied as putative biomarkers of the effects of tACS in the brain during cognitive/sensory task performance. Objective This preliminary study aimed to test the feasibility of individually tailored tACS based on individual P3 (latency and frequency) elicited during a cued premature response task. Thus, tACS frequency was individually tailored to match target-P3 ERO for each participant. Likewise, the target onset in the task was adjusted to match the tACS phase and target-P3 latency. Methods Twelve healthy volunteers underwent tACS in two separate sessions while performing a premature response task. Target-P3 latency and ERO were calculated in a baseline block during the first session to allow a posterior synchronization between the tACS and the endogenous oscillatory activity. The cue and target-P3 amplitudes, delta/theta ERO, and power spectral density (PSD) were evaluated pre and post-tACS blocks. Results Target-P3 amplitude significantly increased after activetACS, when compared to sham. Evoked-delta during cue-P3 was decreased after tACS. No effects were found for delta ERO during target-P3 nor for the PSD and behavioral outcomes. Conclusion The present findings highlight the possible effect of phase synchronization between individualized tACS parameters and endogenous oscillatory activity, which may result in an enhancement of the underlying process (i.e., an increase of target-P3). However, an unsuccessful synchronization between tACS and EEG activity might also result in a decrease in the evoked-delta activity during cue-P3. Further studies are needed to optimize the parameters of endogenous activity and tACS synchronization. The implications of the current results for future studies, including clinical studies, are further discussed since transcranial alternating current stimulation can be individually tailored based on endogenous event-related P3 to modulate responses.Publicação Acesso Aberto Efficacy and safety of TMS and tDCS in memory deficits Alzheimer's disease2024-06-01 - Mendes, Augusto J.; Rocha, Magda; Rodrigues, Pedro F. S.; Fernandes, Sara M.; Conde, Ana; Leite, JorgeTranscranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) are promising non-pharmacological therapeutic options for Alzheimer’s´ Disease (AD). The aim of this meta-analysis is to assess which intervention (i.e., TMS or tDCS) is more effective for memory losses in people with AD. As secondary outcome, safety will be addressed. [...]Publicação Acesso Restrito Functional neuroimaging and behavioral correlates of multisite tDCS as an add-on to language training in a person with post-stroke non-fluent aphasia: A year-long case study2024-05-03 - Mendes, Augusto; Lema, Alberto; Soares, José Miguel; Sampaio, Adriana; Carvalho, Sandra; Leite, JorgeMary, who experienced non-fluent aphasia as a result of an ischemic stroke, received 10 years of personalized language training (LT), resulting in transient enhancements in speech and comprehension. To enhance these effects, multisite transcranial Direct Current Stimulation (tDCS) was added to her LT regimen for 15 sessions. Assessment using the Reliable Change Index showed that this combination improved her left inferior frontal connectivity and speech production for two months and significantly improved comprehension after one month. The results indicate that using multisite transcranial direct current stimulation (tDCS) can improve the effectiveness of language therapy (LT) for individuals with non-fluent aphasia.Publicação Acesso Aberto The emotional movie database (EMDB): an expanded toolkit for emotion research2026-03-16 - Carvalho, Sandra; Coelho, Catarina Gomes; Mendes, Augusto J.; Gonçalves, Óscar F.; Leite, JorgeEmotion-eliciting film clips are widely used in psychological, neuroscientific, and affective computing research as standardized stimuli for the study of emotional responses. The Emotional Movie Database (EMDB) was originally developed to provide silent film clips for emotion research; however, limitations in stimulus diversity motivated its expansion. The present study extends the EMDB by introducing four additional emotional categories—social exclusion, social inclusion, unpleasant landscapes, and extreme sports—together with an expanded set of neutral film clips. Two complementary validation experiments were conducted. Experiment 1 (laboratory-based; n = 117) assessed social exclusion, social inclusion, unpleasant landscapes, and extreme sports clips, whereas Experiment 2 (web-based; n = 128) evaluated social exclusion, social inclusion, and newly recorded neutral clips. Participants rated each clip on valence, arousal, and dominance using the Self-Assessment Manikin (SAM) and reported the discrete emotions experienced. The results provide descriptive normative data for the newly added categories. Social exclusion clips were associated with negative valence (M = 2.16, SD = 1.07) and moderate-to-high arousal (M = 5.97, SD = 2.06), whereas social inclusion clips showed positive valence (M = 7.17, SD = 0.92) and moderate arousal (M = 4.68, SD = 1.72). Unpleasant landscape clips were rated as negatively valenced (M = 2.77, SD = 0.99) with relatively low arousal (M = 4.53, SD = 2.01). Extreme sports clips showed positive valence (M = 6.25, SD = 1.12) and intermediate arousal (M = 5.34, SD = 1.95). Newly recorded neutral clips consistently elicited near-neutral valence (M = 5.11, SD = 0.42) and low arousal (M = 2.31, SD = 1.36), supporting their use as baseline control stimuli. This work provides initial validation evidence and descriptive norms for an expanded set of EMDB film clips, broadening the affective space covered by the database and supporting its use in experimental research on emotion across laboratory-based and online settings.