Leite, Jorge

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Leite

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Jorge

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Jorge Leite

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Jorge Leite obtained his PhD in 2011 from the University of Minho, where he also completed his Psychology Degree in 2005. From 2013 to 2016, he underwent postdoctoral training at the Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School. Currently, he holds the positions of Vice-Rector for Research, Associate Professor, and Coordinator of the CINTESIS.UPT. Throughout his career, he has made significant contributions to the field, with over 70 peer-reviewed publications, including articles in journals, book chapters, and conference proceedings. According to Scopus data, over half of his publications are featured in the top 25% of journals, while 45% are among the top 25% most cited documents globally. He has also supervised numerous MSc dissertations and is currently overseeing four PhD theses. Furthermore, he actively participates in various research projects, taking on roles such as Principal Investigator, Researcher, and Supervisor. These projects have successfully secured over 6M euros in funding. His dedication to his work has been recognized with seven awards and/or honors. Furthermore, he has collaborated with 167 fellow researchers in various scientific endeavors.

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0000-0002-0323-9012
A71F-2404-41CE
03piNtgAAAAJ
47761976700
E-4404-2013

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CINTESIS.UPT - Centro de Investigação em Tecnologias e Serviços de Saúde
Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS.UPT), former I2P, is an R&D unit devoted to the study of cognition and behaviour in context. With an interdisciplinary focus, namely on Education, Translational and Applied Psychology

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Item Type: PublicationAuthor: Gonçalves, Óscar F.Author: Carvalho, SandraAuthor: Leite, JorgeAccess Right: restricted access

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Now showing 1 - 3 of 3
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    PublicationRestricted Access
    Non-pharmacological treatment-related changes of molecular biomarkers in major depressive disorder: A systematic review and meta-analysisTagedEnd
    2023-01-24 - Irwin, Courtney L.; Coelho, Patrícia S.; Kluwe-Schiavon, Bruno; Silva-Fernandes, Anabela; Gonçalves, Óscar F.; Carvalho, Sandra; Leite, Jorge
    Background: Major depressive disorder (MDD) is a serious mood disorder and leading cause of disability. Despite treatment advances, approximately 30% of individuals with MDD do not achieve adequate clinical response. Better understanding the biological mechanism(s) underlying clinical response to specific psychopharmacological interventions may help fine tune treatments in order to further modulate their underlying mechanisms of action. However, little is known regarding the effect of non-pharmacological treatments (NPTs) on candidate molecular biomarker levels in MDD. This review aims to identify molecular biomarkers that may elucidate NPT response for MDD. Methods: We performed a systematic review and a multilevel linear mixed-effects meta-analyses, and a metaregression. Searches were performed in PubMed, Scopus, and PsycINFO in October 2020 and July 2021. Results: From 1387 retrieved articles, 17 and six studies were included in the systematic review and meta-analyses, respectively. Although there was little consensus associating molecular biomarker levels with symptomology and/or treatment response, brain metabolites accessed via molecular biomarker-focused neuroimaging techniques may provide promising information on whether an individual with MDD would respond positively to NPTs. Furthermore, non-invasive brain stimulation interventions significantly increased the expression of neurotrophic factors (NTFs) compared to sham/placebo, regardless of add-on pharmacological treatment. Conclusions: NTFs are candidate biomarkers to fine-tune NIBS for MDD treatment.
  • PublicationRestricted Access
    Modulation of the cognitive event-related potential P3 by transcranial direct current stimulation: Systematic review and meta-analysis
    2022-01 - Mendes, Augusto J.; Pacheco-Barrios, Kevin; Lema, Alberto; Gonçalves, Óscar F.; Fregni, Felipe; Carvalho, Sandra; Leite, Jorge
    Transcranial direct current stimulation (tDCS) has been widely used to modulate cognition and behavior. However, only a few studies have been probing the brain mechanism underlying the effects of tDCS on cognitive processing, especially throughout electrophysiological markers, such as the P3. This meta-analysis assessed the effects of tDCS in P3 amplitude and latency during an oddball, n-back, and Go/No-Go tasks, as well as during emotional processing. A total of 36 studies were identified, but only 23 were included in the quantitative analysis. The results show that the parietal P3 amplitude increased during oddball and n-back tasks, mostly after anodal stimulation over the left dorsolateral prefrontal cortex (p = 0.018, SMD = 0.4) and right inferior frontal gyrus (p < 0.001, SMD = 0.669) respectively. These findings suggest the potential usefulness of the parietal P3 ERP as a marker of tDCS-induced effects during task performance. Nonetheless, this study had a low number of studies and the presence of considerable risk of bias, highlighting issues to be addressed in the future.
  • PublicationRestricted Access
    Mind wandering: Tracking perceptual decoupling, mental improvisation, and mental navigation
    2020-10-15 - Gonçalves, Óscar F.; Silva, Mariana Rachel Dias da; Carvalho, Sandra; Coelho, Patrícia; Lema, Alberto; Mendes, Augusto J.; Branco, Diogo; Collus, Jorge; Boggio, Paulo S.; Leite, Jorge
    Background: Mind wandering is a prevalent phenomenon. However, the concept of mind wandering is associated with distinct and often orthogonal concepts, and research- ers are still debating the best strategies to gain access to mind-wandering processes. Nonetheless, there is a progressive acknowledgment that mind wandering is a multi- dimensional and heterogeneous construct. We argue that to fully understand mind wandering, we need to look at dimensions assessing the process (i.e., perceptual decoupling), dynamics (i.e., mental improvisation), and content (i.e., mental naviga- tion). Objective: The objective of this study was to develop a self-report measure of mind wandering—the Mind Wandering Inventory (MWI)—to capture the heterogene- ity of mind wandering in terms of process, dynamic, and content components. Method: Five language versions of the MWI were administered to an international sample of 1,162 individuals. Results: Results showed that the MWI had good levels of internal consistency. In terms of internal structure, we found a first factor to index perceptual decoupling, a second to index mental improvisation, and a third to index mental navigation. Additionally, a study of concurrent validity with Spontaneous and Delib- erate Mind Wandering scales suggested that MWI has significant correlations with previous mind-wandering scales and that factors 1 (perceptual decoupling) and 2 (mental improvisation) seemed to be more closely associated with spontaneous than deliberate mind wandering. Finally, individuals coming from sciences major back- ground reported increased levels of mind wandering when compared with participants from both health, social and human sciences background.