Leite, Jorge

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Jorge Leite


Jorge Leite obtained his PhD in 2011 from the University of Minho, where he also completed his Psychology Degree in 2005. From 2013 to 2016, he underwent postdoctoral training at the Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School. Currently, he holds the positions of Vice-Rector for Research, Associate Professor, and Coordinator of the CINTESIS.UPT. Throughout his career, he has made significant contributions to the field, with over 70 peer-reviewed publications, including articles in journals, book chapters, and conference proceedings. According to Scopus data, over half of his publications are featured in the top 25% of journals, while 45% are among the top 25% most cited documents globally. He has also supervised numerous MSc dissertations and is currently overseeing four PhD theses. Furthermore, he actively participates in various research projects, taking on roles such as Principal Investigator, Researcher, and Supervisor. These projects have successfully secured over 6M euros in funding. His dedication to his work has been recognized with seven awards and/or honors. Furthermore, he has collaborated with 167 fellow researchers in various scientific endeavors.

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CINTESIS.UPT - Centro de Investigação em Tecnologias e Serviços de Saúde
Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS.UPT), former I2P, is an R&D unit devoted to the study of cognition and behaviour in context. With an interdisciplinary focus, namely on Education, Translational and Applied Psychology

Resultados da pesquisa

A mostrar 1 - 4 de 4
  • PublicaçãoAcesso Restrito
    Modulation of the cognitive event-related potential P3 by transcranial direct current stimulation: Systematic review and meta-analysis
    2022-01 - Mendes, Augusto J.; Pacheco-Barrios, Kevin; Lema, Alberto; Gonçalves, Óscar F.; Fregni, Felipe; Carvalho, Sandra; Leite, Jorge
    Transcranial direct current stimulation (tDCS) has been widely used to modulate cognition and behavior. However, only a few studies have been probing the brain mechanism underlying the effects of tDCS on cognitive processing, especially throughout electrophysiological markers, such as the P3. This meta-analysis assessed the effects of tDCS in P3 amplitude and latency during an oddball, n-back, and Go/No-Go tasks, as well as during emotional processing. A total of 36 studies were identified, but only 23 were included in the quantitative analysis. The results show that the parietal P3 amplitude increased during oddball and n-back tasks, mostly after anodal stimulation over the left dorsolateral prefrontal cortex (p = 0.018, SMD = 0.4) and right inferior frontal gyrus (p < 0.001, SMD = 0.669) respectively. These findings suggest the potential usefulness of the parietal P3 ERP as a marker of tDCS-induced effects during task performance. Nonetheless, this study had a low number of studies and the presence of considerable risk of bias, highlighting issues to be addressed in the future.
  • PublicaçãoAcesso Aberto
    Efficacy and safety of repetitive transcranial magnetic stimulation and transcranial direct current stimulation in memory deficits in patients with Alzheimer's disease: Meta-analysis and systematic review
    2024-03-01 - Mendes, Augusto J.; Leite, Jorge; Fernandes, Sara M.; Rodrigues, Pedro F. S.; Conde, Ana; Rocha, Magda
    Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are two of the most used non-pharmacological interventions for Alzheimer's Disease (AD). However, most of the clinical trials have focused on evaluating the effects on global cognition and not on specific cognitive functions. Therefore, considering that memory loss is one of the hallmark symptoms of AD, we aim to assess the efficacy and safety of tDCS and rTMS in memory deficits. For that, multilevel random effect models were performed considering the standardized mean difference (SMD) between active and sham stimulation. A total of 19 studies with 411 participants demonstrated positive effects in memory after tDCS (SMD=0.20, p = 0.04) and rTMS (SMD=0.44, p = 0.001). Subgroup analysis revealed that tDCS had greater efficacy when administered in temporal regions (SMD=0.32, p = 0.04), whereas rTMS was superior when applied in frontal regions (SMD=0.61, p < 0.001). Therefore, depending on the brain region of stimulation, both interventions produced a positive effect on memory symptoms in AD patients. Finally, the safety of both techniques was observed in the AD population after the reporting of almost no serious events.
  • PublicaçãoAcesso Aberto
    Transcranial direct current stimulation decreases P3 amplitude and inherent Delta activity during a waiting impulsivity paradigm: Crossover study
    2024-02-07 - Mendes, Augusto J.; Galdo-Álvarez, Santiago; Lema, Alberto; Carvalho, Sandra; Leite, Jorge
    The inability to wait for a target before initiating an action (i.e., waiting impulsivity) is one of the main features of addictive behaviors. Current interventions for addiction, such as transcranial Direct Current Stimulation (tDCS), have been suggested to improve this inability. Nonetheless, the effects of tDCS on waiting impulsivity and underlying electrophysiological (EEG) markers are still not clear. Therefore, this study aimed to evaluate the effects of neuromodulation over the right inferior frontal gyrus (rIFG) on the behavior and EEG markers of reward anticipation (i.e., cue and target-P3 and underlying delta/theta power) during a premature responding task. For that, forty healthy subjects participated in two experimental sessions, where they received active and sham tDCS over the rIFG combined with EEG recording during the task. To evaluate transfer effects, participants also performed two control tasks to assess delay discounting and motor inhibition. The active tDCS decreased the cue-P3 and target-P3 amplitudes, as well as delta power during target-P3. While no tDCS effects were found for motor inhibition, active tDCS increased the discounting of future rewards when compared to sham. These findings suggest a tDCS-induced modulation of the P3 component and underlying oscillatory activity during waiting impulsivity and the discounting of future rewards.
  • PublicaçãoAcesso Restrito
    Mind wandering: Tracking perceptual decoupling, mental improvisation, and mental navigation
    2020-10-15 - Gonçalves, Óscar F.; Silva, Mariana Rachel Dias da; Carvalho, Sandra; Coelho, Patrícia; Lema, Alberto; Mendes, Augusto J.; Branco, Diogo; Collus, Jorge; Boggio, Paulo S.; Leite, Jorge
    Background: Mind wandering is a prevalent phenomenon. However, the concept of mind wandering is associated with distinct and often orthogonal concepts, and research- ers are still debating the best strategies to gain access to mind-wandering processes. Nonetheless, there is a progressive acknowledgment that mind wandering is a multi- dimensional and heterogeneous construct. We argue that to fully understand mind wandering, we need to look at dimensions assessing the process (i.e., perceptual decoupling), dynamics (i.e., mental improvisation), and content (i.e., mental naviga- tion). Objective: The objective of this study was to develop a self-report measure of mind wandering—the Mind Wandering Inventory (MWI)—to capture the heterogene- ity of mind wandering in terms of process, dynamic, and content components. Method: Five language versions of the MWI were administered to an international sample of 1,162 individuals. Results: Results showed that the MWI had good levels of internal consistency. In terms of internal structure, we found a first factor to index perceptual decoupling, a second to index mental improvisation, and a third to index mental navigation. Additionally, a study of concurrent validity with Spontaneous and Delib- erate Mind Wandering scales suggested that MWI has significant correlations with previous mind-wandering scales and that factors 1 (perceptual decoupling) and 2 (mental improvisation) seemed to be more closely associated with spontaneous than deliberate mind wandering. Finally, individuals coming from sciences major back- ground reported increased levels of mind wandering when compared with participants from both health, social and human sciences background.