Leite, Jorge
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Leite
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Jorge
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Jorge Leite
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Jorge Leite obtained his PhD in 2011 from the University of Minho, where he also completed his Psychology Degree in 2005. From 2013 to 2016, he underwent postdoctoral training at the Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School. Currently, he holds the positions of Vice-Rector for Research, Associate Professor, and Coordinator of the CINTESIS.UPT. Throughout his career, he has made significant contributions to the field, with over 70 peer-reviewed publications, including articles in journals, book chapters, and conference proceedings. According to Scopus data, over half of his publications are featured in the top 25% of journals, while 45% are among the top 25% most cited documents globally. He has also supervised numerous MSc dissertations and is currently overseeing four PhD theses. Furthermore, he actively participates in various research projects, taking on roles such as Principal Investigator, Researcher, and Supervisor. These projects have successfully secured over 6M euros in funding. His dedication to his work has been recognized with seven awards and/or honors. Furthermore, he has collaborated with 167 fellow researchers in various scientific endeavors.
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47761976700
E-4404-2013Projetos de investigação
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CINTESIS.UPT - Centro de Investigação em Tecnologias e Serviços de Saúde
Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS.UPT), former I2P, is an R&D unit devoted to the study of cognition and behaviour in context. With an interdisciplinary focus, namely on Education, Translational and Applied Psychology
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Publicação Acesso Aberto Editorial: Optimization strategies for pain management with neuromodulation2022-09-15 - Pacheco-Barrios, Kevin; Carvalho, Sandra; Caumo, Wolnei; Fregni, Felipe; Leite, JorgeChronic pain is a high-priority global health issue due to its high prevalence, impact on quality of life, and cost (1). In most cases, chronic pain is challenging to manage, and the existing treatment modalities have reported frequent and severe adverse events, including gastritis (2), cardiovascular complications [...]Publicação Acesso Restrito Modulation of the cognitive event-related potential P3 by transcranial direct current stimulation: Systematic review and meta-analysis2022-01 - Mendes, Augusto J.; Pacheco-Barrios, Kevin; Lema, Alberto; Gonçalves, Óscar F.; Fregni, Felipe; Carvalho, Sandra; Leite, JorgeTranscranial direct current stimulation (tDCS) has been widely used to modulate cognition and behavior. However, only a few studies have been probing the brain mechanism underlying the effects of tDCS on cognitive processing, especially throughout electrophysiological markers, such as the P3. This meta-analysis assessed the effects of tDCS in P3 amplitude and latency during an oddball, n-back, and Go/No-Go tasks, as well as during emotional processing. A total of 36 studies were identified, but only 23 were included in the quantitative analysis. The results show that the parietal P3 amplitude increased during oddball and n-back tasks, mostly after anodal stimulation over the left dorsolateral prefrontal cortex (p = 0.018, SMD = 0.4) and right inferior frontal gyrus (p < 0.001, SMD = 0.669) respectively. These findings suggest the potential usefulness of the parietal P3 ERP as a marker of tDCS-induced effects during task performance. Nonetheless, this study had a low number of studies and the presence of considerable risk of bias, highlighting issues to be addressed in the future.Publicação Acesso Aberto Longitudinal Clinical Trial Recruitment and Retention Challenges in the Burn Population: Lessons Learned from a Trial Examining a Novel Intervention for Chronic Neuropathic Symptoms2019 - Ohrtman, Emily A.; Zaninotto, Ana Luiza; Carvalho, Sandra; Shie, Vivian L.; Ianni, Corinne Rose; Kazis, Lewis E.; Ross Zafonte, Ross Zafonte; Ryan, Colleen M.; Schneider, Jeffrey C.; Fregni, Felipe; Leite, JorgeLong-term trials are key to understanding chronic symptoms such as pain and itch. However, challenges such as high attrition rates and poor recruitment are common when conducting research. The aim of this work was to explore these issues within a long-term randomized control trial using transcranial direct current stimulation to treat pain and itch. This parallel double blinded, placebo-controlled randomized trial was comprised of 15 transcranial direct current stimulation visits and 7 follow-up visits. Participants were over the age of 18, had a burn injury that occurred at least 3 weeks before enrollment, and reported having pain and/or itch that was moderate to severe in intensity. A total of 31 subjects were randomized into either an active or sham transcranial direct current stimulation groups. There were no significant differences between the groups in terms of age, race, education, baseline depression, or anxiety. The median dropout time was at visit 19 (visit 16 [SE = 1.98] for the sham group and visit 19 [SE = 1.98] for the active group). Analysis showed no differences in the dropout rate between groups [χ2(1) = 0.003, P = .954]. The dropout rate was 46.7% for the sham group and 43.8% for the active group. Overall, 45.2% of the subjects dropped out of the trial. Long-term clinical trials are an essential part of evaluating interventions for symptoms such as chronic pain and itch. However, as seen in this trial, long-term studies in the burn population often face recruitment and adherence challenges.Publicação Acesso Aberto Speed of Processing (SoP) Training Plus α-tACS in people with mild cognitive impairment: a double blind, parallel, placebo controlled trial study protocol2022-07-14 - Gonçalves, Óscar F.; Carvalho, Sandra; Leite, JorgeSeveral cognitive training programs, alone or in combination with non-invasive brain stimulation have been tested in order to ameliorate age-related cognitive impairments, such as the ones found in Mild Cognitive Impairment (MCI). However, the effects of Cognitive Training (CT)—combined or not—with several forms of non-invasive brain stimulation have been modest at most. We aim to assess if Speed of Processing (SoP) training combined with alpha transcranial alternating current stimulation (a-tACS) is able to increase speed of processing as assessed by the Useful Field of View (UFOV), when comparing to SoP training or active a-tACS alone. Moreover, we want to assess if those changes in speed of processing transfer to other cognitive domains, such as memory, language and executive functioning by using the NIH EXAMINER. We also want to test the mechanisms underlying these interventions, namely brain connectivity and coherence as assessed by electroencephalography (EEG). To that purpose, our proposal is to enroll 327 elders diagnosed with MCI in a double-blinded, parallel randomized clinical trial assessing the effects of combining SoP with alpha endogenous tACS (either active or sham) in people with MCI. Participants will perform an intervention that will last for 15 sessions. For the first 3 weeks, participants will receive nine sessions of the intervention, and then will receive two sessions per week (i.e., booster) for the following 3 weeks. They will then be assessed at 1, 3, and 6 months after the intervention has ended. This will allow us to detect the immediate, and long-term effects of the interventions, as well as to probe the mechanisms underlying its effects.Publicação Acesso Aberto Digitalized transcranial electrical stimulation: a consensus statement2022-09-05 - Brunoni, André R.; Ekhtiari, Hamed; Antal, Andrea; Auvichayapat, Paradee; Baeken, Chris; Benseñor, Isabela M; Bikson, Marom; Boggio, Paulo; Borroni, Barbara; Brighina, Filippo; Brunelin, Erome; Carvalho, Sandra; Caumo, Wolnei; Ciechanski, Patrick; Charvet, Leigh; Clark, Vincent P; Kadosh, Roi Cohen; Cotelli, Maria; Datta, Abhishek; Deng, Zhi-De; Raedt, Rudi De; Ridder, Dirk De; Fitzgerald, Paul B; Floel, Agnes; Frohlich, Flavio; George, Mark S; Ghobadi-Azbari, Peyman; Goerigk, Stephan; Hamilton, Roy H; Jaberzadeh, Shapour J; Hoy, Kate; Kidgell, Dawson J; Zonoozi, Arash Khojasteh; Kirton, Adam; Laureys, Steven; Lavidor, Michal; Lee, Kiwon; Lisanby, Sarah H; Loo, Colleen; Martin, Donel M; Miniussi, Carlo; Mondino, Marine; Monte-Silva, Katia; Morales-Quezada, Leon; Nitsche, Michael A; Okano, Alexandre H; Oliveira, Claudia S; Onarheim, Balder; Pacheco-Barrios, Kevin; Padberg, Frank; Nakamura-Palacios, Ester M; Palm, Ulrich; Paulus, Walter; Plewnia, Christian; Priori, Alberto; Rajji, Tarek K; Razza, Lais B; Rehn, Erik M; Ruffini, Giuliov; Schellhorn, Klaus; Zare-Bidoky, Mehran; Simis, Marcel; Skorupinski, Pawel; Suen, Paulo; Thibaut, Aurore; Valiengo, Leandro C L; Vanderhasselt, Marie-Anne; Vanneste, Sven; Venkatasubramanian, Ganesan; Violante, Ines R; Wexler, Anna; Woods, Adam J; Fregni, Felipe; Leite, JorgeObjective: Although relatively costly and non-scalable, non-invasive neuromodulation interventions are treatment alternatives for neuropsychiatric disorders. The recent developments of highly-deployable transcranial electric stimulation (tES) systems, combined with mobile-Health technologies, could be incorporated in digital trials to overcome methodological barriers and increase equity of access. The study aims are to discuss the implementation of tES digital trials by performing a systematic scoping review and strategic process mapping, evaluate methodological aspects of tES digital trial designs, and provide Delphi-based recommendations for implementing digital trials using tES. Methods: We convened 61 highly-productive specialists and contacted 8 tES companies to assess 71 issues related to tES digitalization readiness, and processes, barriers, advantages, and opportunities for implementing tES digital trials. Delphi-based recommendations (>60% agreement) were provided. Results: The main strengths/opportunities of tES were: (i) non-pharmacological nature (92% of agreement), safety of these techniques (80%), affordability (88%), and potential scalability (78%). As for weaknesses/ threats, we listed insufficient supervision (76%) and unclear regulatory status (69%). Many issues related to methodological biases did not reach consensus. Device appraisal showed moderate digitalization readiness, with high safety and potential for trial implementation, but low connectivity. Conclusions: Panelists recognized the potential of tES for scalability, generalizability, and leverage of digital trials processes; with no consensus about aspects regarding methodological biases. Significance: We further propose and discuss a conceptual framework for exploiting shared aspects between mobile-Health tES technologies with digital trials methodology to drive future efforts for digitizing tES trials.Publicação Acesso Aberto The acute impact of the early stages of COVID-19 pandemic in people with pre-existing psychiatric disorders: A systematic review2022-04-23 - Carvalho, Sandra; Coelho, Catarina G.; Kluwe-Schiavon, Bruno; Magalhães, Juliana; Leite, JorgePeople with pre-pandemic health conditions are more vulnerable and more likely to suffer greater psychosocial impact due to the current COVID-19 pandemic and the lockdown measures. Thus, the objective of this work was to systematically review the impact of the early stages COVID-19 pandemic on people with pre-existing psychiatric disorders. The search was performed between 23 January and 2 September 2021 in PubMed, PsycINFO, and EMBASE. A total of 4167 published results were identified; however, only 49 were included in this review. Results show that there was considerable heterogeneity among studies, which resulted in a low consensus. However, it seems that the impact of the first stage of the COVID-19 pandemic on psychiatric disorders was two-fold: (1) an overall effect, in which people suffering from psychiatric disorders in general experienced more psychological distress and anxiety when compared to people who had no psychiatric diagnosis, and (2) a condition-specific effect, namely in people suffering from eating disorders and obsessive compulsive disorders. Moreover, the current work highlights that there were also some external factors that were related to worsening symptoms. For instance, unemployment or experiencing work and financial difficulties can be a trigger for greater distress during the pandemic for people with mood disorders, and being alone and in social isolation during the COVID-19 pandemic may actually increase substance use and relapse rates. Further studies are needed to prospectively investigate the long-term effects of the current COVID-19 pandemic on people with (pre)-existing psychiatric conditions and on the onset or deterioration of psychiatric-related symptoms in a larger number of participants, as well as exploring the long-term effects of the current pandemic on mental health.Publicação Acesso Restrito Non-pharmacological treatment-related changes of molecular biomarkers in major depressive disorder: A systematic review and meta-analysisTagedEnd2023-01-24 - Irwin, Courtney L.; Coelho, Patrícia S.; Kluwe-Schiavon, Bruno; Silva-Fernandes, Anabela; Gonçalves, Óscar F.; Carvalho, Sandra; Leite, JorgeBackground: Major depressive disorder (MDD) is a serious mood disorder and leading cause of disability. Despite treatment advances, approximately 30% of individuals with MDD do not achieve adequate clinical response. Better understanding the biological mechanism(s) underlying clinical response to specific psychopharmacological interventions may help fine tune treatments in order to further modulate their underlying mechanisms of action. However, little is known regarding the effect of non-pharmacological treatments (NPTs) on candidate molecular biomarker levels in MDD. This review aims to identify molecular biomarkers that may elucidate NPT response for MDD. Methods: We performed a systematic review and a multilevel linear mixed-effects meta-analyses, and a metaregression. Searches were performed in PubMed, Scopus, and PsycINFO in October 2020 and July 2021. Results: From 1387 retrieved articles, 17 and six studies were included in the systematic review and meta-analyses, respectively. Although there was little consensus associating molecular biomarker levels with symptomology and/or treatment response, brain metabolites accessed via molecular biomarker-focused neuroimaging techniques may provide promising information on whether an individual with MDD would respond positively to NPTs. Furthermore, non-invasive brain stimulation interventions significantly increased the expression of neurotrophic factors (NTFs) compared to sham/placebo, regardless of add-on pharmacological treatment. Conclusions: NTFs are candidate biomarkers to fine-tune NIBS for MDD treatment.Publicação Acesso Aberto The effects of direct current stimulation and random noise stimulation on attention networks2021-03-18 - Lema, Alberto; Carvalho, Sandra; Fregni, Felipe; Gonçalves, Óscar F.; Leite, JorgeAttention is a complex cognitive process that selects specific stimuli for further processing. Previous research suggested the existence of three attentional networks: alerting, orienting and executive. However, one important topic is how to enhance the efficiency of attentional networks. In this context, understanding how this system behaves under two different modulatory conditions, namely transcranial direct current stimulation (tDCS) and transcranial Random Noise Stimulation (tRNS), will provide important insights towards the understanding of the attention network system. Twenty-seven healthy students took part on a randomized single-blinded crossover study, testing the effects that involved three modalities of unilateral stimulation (tRNS, anodal tDCS, and sham) over the DLPFC, during the performance of the attention network test (ANT) in three different conditions: standard, speed and accuracy. Results showed that tRNS was able to increase attention during more complex situations, namely by increasing alerting and decreasing conflict effect in the executive network. Under the Speed condition, tRNS increased efficiency of the alerting network, as well as under the more demanding conflict network, tRNS overall increased the performance when comparing to sham. No statistical significant effects of tDCS were observed. These results are compatible with the attention requiring the synchronization of pre-existing networks, rather the reinforcement or creation of new pathways.Publicação Acesso Aberto Probing the relationship between late endogenous ERP components with fluid intelligence in healthy older adults2020-07-07 - Teixeira-Santos, Ana C.; Pinal, Diego; Pereira, Diana R.; Carvalho, Sandra; Sampaio, Adriana; Leite, JorgeThe world population is rapidly aging, bringing together the necessity to better understand the advancing age. This characterization may be used to aid early diagnosis and to guide individually-tailored interventions. While some event-related potential (ERP) components, such as the P300 and late positive complex (LPC), have been associated with fluid intelligence (Gf) in young population; little is known whether these associations hold for older people. Therefore, the main goal of this study was to assess whether these ERP components are associated with Gf in the elderly. Fifty-seven older adults performed a continuous performance task (CPT) and a visual oddball paradigm while EEG was recorded. Participants were divided into two groups, according to their performance in the Raven’s Advanced Progressive Matrices test: high-performance (HP) and low-performance (LP). Results showed that the HP group, compared to the LP group, had higher LPC amplitudes in the CPT and shorter P300 latencies in the oddball task, highlighting the role of ERP components as a potential electrophysiological proxy of Gf abilities in the elderly.Publicação Acesso Restrito Functional neuroimaging and behavioral correlates of multisite tDCS as an add-on to language training in a person with post-stroke non-fluent aphasia: A year-long case study2024-05-03 - Mendes, Augusto; Lema, Alberto; Soares, José Miguel; Sampaio, Adriana; Carvalho, Sandra; Leite, JorgeMary, who experienced non-fluent aphasia as a result of an ischemic stroke, received 10 years of personalized language training (LT), resulting in transient enhancements in speech and comprehension. To enhance these effects, multisite transcranial Direct Current Stimulation (tDCS) was added to her LT regimen for 15 sessions. Assessment using the Reliable Change Index showed that this combination improved her left inferior frontal connectivity and speech production for two months and significantly improved comprehension after one month. The results indicate that using multisite transcranial direct current stimulation (tDCS) can improve the effectiveness of language therapy (LT) for individuals with non-fluent aphasia.